P-103 Operative risk factors for clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy: A prospective multicenter cohort study

Pancreatic fistula remains the most dangerous complication after pancreatoduodenectomy. This study aimed to identify operative risk factors for clinically relevant postoperative pancreatic was a prospective multicenter cohort that investigated association between and in 107 patients who underwent pancreatoduodenectomy at three tertiary centers from August 2017 July 2022. The incidence of 26.2%. With univariate analysis, soft texture (OR 7.304, 95% CI 2.732-19.531, P < 0.0001), small main duct diameter 4.645, 1.766-12.221, 0.001), right-sided transection 4.560, 1.810-11.488, absorbable suture 2.509, 1.027-6.128, = 0.040), pancreatico-enteric anastomosis invagination technique 0.352, 0.139-0.894, 0.025), non-stented drainage 0.234, 0.094-0.581, internal 8.333, 2.025-34.286, long anastomotic time 0.336, 0.138-0.818, 0.014), R1 resection margin 0.339, 0.134-0.857, 0.019) were fistula. Multivariate analysis identified four independent fistula: (1) 0.219, 0.061-0.792, 0.021), (2) 0.280, 0.086-0.910, 0.034), (3) 0.168, 0.032-0.881, 0.035), (4) 3.771, 1.147-12.401, 0.029). is reduced significantly by left-sided drainage. Soft are